2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W040231
    Fmoc-NH-PEG3-CH2CH2COOH 867062-95-1 99.79%
    Fmoc-NH-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG3-CH2CH2COOH
  • HY-W010764
    Biotin-PEG2-Mal 305372-39-8 99.64%
    Biotin-PEG2-Mal is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Biotin-PEG2-Mal
  • HY-140453
    Azido-PEG6-acid 361189-66-4 99.77%
    Azido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-acid
  • HY-140915
    Biotin-PEG4-Picolyl azide 2222687-71-8 98.66%
    Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-Picolyl azide
  • HY-W021787
    NH2-PEG4-CH2CH2COOH 663921-15-1 99.88%
    NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG4-CH2CH2COOH
  • HY-120702
    N-Boc-PEG5-bromide 1392499-32-9
    N-Boc-PEG5-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG5-bromide
  • HY-134720
    Amine-PEG4-Desthiobiotin 2306109-91-9 99.23%
    Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG4-Desthiobiotin
  • HY-W017755
    (R)-Azetidine-2-carboxylic acid 7729-30-8 99.86%
    (R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be
    (R)-Azetidine-2-carboxylic acid
  • HY-W067489
    NH2-PEG1-CH2CH2-Boc 1260092-46-3 99.83%
    NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG1-CH2CH2-Boc
  • HY-141263
    Methyltetrazine-acid 1380500-88-8 98.61%
    Methyltetrazine-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-acid
  • HY-130436
    Acid-C2-PEG4-C2-NHS ester 1343476-41-4 ≥98.0%
    Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-C2-PEG4-C2-NHS ester
  • HY-140797
    Azido-PEG2-alcohol 139115-90-5 99.49%
    Azido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-alcohol
  • HY-140177
    Amino-PEG12-acid 1415408-69-3 ≥98.0%
    Amino-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG12-acid
  • HY-W014099
    Boc-NH-C4-acid 27219-07-4 99.85%
    Boc-NH-C4-acid is a PROTAC linker, which belongs to a Alkyl/ether linker. Boc-NH-C4-acid can be used in the synthesis of the compound PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
    Boc-NH-C4-acid
  • HY-140208
    2,2-Oxybis(ethylamine) 2752-17-2 99.95%
    22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2,2-Oxybis(ethylamine)
  • HY-133479
    Tetrazine-Ph-NHCO-C3-NHS ester 1244040-64-9 98.28%
    Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-NHCO-C3-NHS ester
  • HY-42427
    NH2-PEG2-CH2-Boc 1948273-09-3
    NH2-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG2-CH2-Boc
  • HY-W025812
    Boc-NH-PEG2-CH2CH2COOH 1365655-91-9
    Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG2-CH2CH2COOH
  • HY-126886
    Mal-PEG1-NHS ester 1807518-72-4 99.63%
    Mal-PEG1-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-NHS ester is PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG1-NHS ester
  • HY-140459
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9 ≥98.0%
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
PROTAC Linkers Isoform Comparison

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